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HF definition: increase in either LVEDP or LVEDV
HF = less CO measured by baroreceptors
Three major areas: carotid arteries (CNIX) and aorta sinuses (CNX), nephron (JGA), atria (ANP)
Sympathetic system: ACh to NE
signals 3 different areas- heart (SA node and contractility myocytes), adrenal medulla (catecholamines), kidney (JGA and RAAAS system)
PKA (from Gs) does three things: open calcium channels (like DAG), affects SERCA to draw more calcium into SER and inhibits phospholandin (inhibitor) = intracellular Ca2+ which increases contractility
angiotensin II is also a vasoconstrictor
concentric = due to increased afterload, units get added parallel or on top of each other. ventricle remains the same but thickness increases
eccentric = due to increased preload, units get added in series or next to each other. Ventricle gets bigger but thickness decreases
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