Introduction to the Microbial World
You do not have access to this note.
True pathogen- virulence factors
Organisms of the microbiome- mechanical failures of innate barrier- often mixed
Microbes of immunodeficiency disease- single microbes- specific to a particular immune defect
Prion - infectious proteins- Acellular
Virus- Acellular- electron microscope- DNA or RNA-obligate intracellular( can't live or procreate without having a cell to live in)- Rx- Anti fusion, anti nucleic acid, anti release
Prokaryote (bacteria)- light microscope- Cells with no internal membrane bound organelles (no nucleus, no mitochondria, no ER)- replicate cont. by binary fission, asexual- mono and polycistronic mRNA- no introns- 70s ribosomes - cell membranes without sterols- cell wall- peptidoglycan- Rx- Anti cell wall penicillin, cephalosporins, vancomycin- Anti 70s ribosomes- tetracycline, macrolides, lincosomides
#Mycoplasma - unusual prok. - has sterols in membrane and doesn't have a cell wall.
Bacteria have DNA and RNA
Eukaryote- light microscope to naked eye- DNA and RNA
fungus- ergosterol- complex carbohydrate cell wall
Anti- ergosterol- nystatin, imidazoles, terbinafine
- Anti chitin- Nikkomycin
Parasite- cholesterol- most anti parasitic drugs have some toxicity for human cells- more difficult to treat
Epidemiology of infectious diseases
Normal flora- Assist digestion and producs Vitamin K for
There was a problem reporting this post.
Please confirm you want to block this member.
You will no longer be able to:
Please note: This action will also remove this member from your connections and send a report to the site admin. Please allow a few minutes for this process to complete.