Molecular Components of Cells
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Topoisomerase has clinical relevance due to it being a target for pharmaceuticals:
and for anti-topoisomerase I antibodies (anti-Scl-70 antibodies) in autoimmune diseases like:
CREST syndrome (lesser extent)
Example of targeting DNA polymerase: Acyclovir
empiric therapy for pts with encephalitis or known HSV encephalopathy
The drug has no effect on human DNA polymerase function HOWEVER, within the virus, the DNA polymerase becomes an obligate chain termination point where it can no longer replicate.
Different Types of DNA Mutations Possible
Point Mutations: a broad category of mutations in which a base pair is altered and includes silent mutations, nonsense and missense mutations.
Silent mutation: base pair is changed but amino acid remains the same
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